Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer that begins in basal cells of the skin is called basal cell carcinoma.Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues. Although advancements in the treatment of the different types of cancers in the clinic, more and more tumor cells become resistant to chemotherapy and/or radiotherapy. In 2009, 1,479,350 (does not include nonmelanoma skin cancers) new cases are expected and 562,340 persons are projected to die from cancer in the United States (http://www.cancer.gov/cancertopics/what-is-cancer). Therefore, a safe and effective treatment remains a critical need.
Cancer types can be grouped into broader categories.
NCI's Cancer Stat Fact Sheets provide frequently requested cancer statistics for a number of cancer types.
SOURCE: National Cancer Institute To learn more »
Field of the Invention
We bring new discovery and new concepts through innovation and growth to the pharmaceutical industry.
The invention is within the scope of oncolytic virotherapy.
What is oncolytic virus (OV)?
OV is a special virus, either naturally occurring or genetically modified, selectively targets and destroys tumor cells whilst leaving surrounding non-malignant cells unharmed
RVLYSIS vs other OVs
Preferentially kills tumor cells
Selectively Induces apoptosis in tumor cells
Allows interferon to achieve high local concentration
Multiple Mechanics Action of RVLYSIS
Function of local IFN
Directly kills tumor cells
Limits viral replication in normal cells around
Induces systemic immunoresponses to indirectly antitumor